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Phosphate-dependent aggregation of [KL](n) peptides affects their membranolytic activity

In this study, we investigate how the length of amphiphilic β-sheet forming peptides affects their interaction with membranes. Four polycationic model peptides with lengths from 6 to 18 amino acids were constructed from simple Lys-Leu repeats, giving [KL](n=3,5,7,9). We found that (1) they exhibit a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Strandberg, Erik, Schweigardt, Fabian, Wadhwani, Parvesh, Bürck, Jochen, Reichert, Johannes, Cravo, Haroldo L. P., Burger, Luisa, Ulrich, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378186/
https://ncbi.nlm.nih.gov/pubmed/32704013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69162-0
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