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Synergistic Insertion of Antimicrobial Magainin-Family Peptides in Membranes Depends on the Lipid Spontaneous Curvature

PGLa and magainin 2 (MAG2) are amphiphilic antimicrobial peptides from frog skin with known synergistic activity. The orientation of the two helices in membranes was studied using solid-state (15)N-NMR, for each peptide alone and for a 1:1 mixture of the peptides, in a range of different lipid syste...

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Detalhes bibliográficos
Main Authors: Strandberg, Erik, Zerweck, Jonathan, Wadhwani, Parvesh, Ulrich, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602749/
https://ncbi.nlm.nih.gov/pubmed/23528099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.01.047
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