(2)H-NMR and MD Simulations Reveal Membrane-Bound Conformation of Magainin 2 and Its Synergy with PGLa

Magainin 2 (MAG2) and PGLa are two α-helical antimicrobial peptides found in the skin of the African frog Xenopus laevis. They act by permeabilizing bacterial membranes and exhibit an exemplary synergism. Here, we determined the detailed molecular alignment and dynamical behavior of MAG2 in oriented...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Strandberg, Erik, Horn, Diana, Reißer, Sabine, Zerweck, Jonathan, Wadhwani, Parvesh, Ulrich, Anne S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Membranes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113259/
https://ncbi.nlm.nih.gov/pubmed/27851939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.012
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