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(2)H-NMR and MD Simulations Reveal Membrane-Bound Conformation of Magainin 2 and Its Synergy with PGLa

Magainin 2 (MAG2) and PGLa are two α-helical antimicrobial peptides found in the skin of the African frog Xenopus laevis. They act by permeabilizing bacterial membranes and exhibit an exemplary synergism. Here, we determined the detailed molecular alignment and dynamical behavior of MAG2 in oriented...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Strandberg, Erik, Horn, Diana, Reißer, Sabine, Zerweck, Jonathan, Wadhwani, Parvesh, Ulrich, Anne S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113259/
https://ncbi.nlm.nih.gov/pubmed/27851939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.012
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