Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition

DNA recognition by transcription activator-like effector (TALE) proteins is mediated by tandem repeats that specify nucleotides through repeat-variable diresidues. These repeat-variable diresidues form direct and sequence-specific contacts to DNA bases; hence, TALE–DNA interaction is sensitive to DN...

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Pubblicato in:Nat Commun
Autori principali: Zhang, Yuan, Liu, Lulu, Guo, Shengjie, Song, Jinghui, Zhu, Chenxu, Yue, Zongwei, Wei, Wensheng, Yi, Chengqi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638953/
https://ncbi.nlm.nih.gov/pubmed/29026078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00860-6
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