Transgenic expression of human cytokines in immunodeficient mice does not facilitate myeloid expansion of BCR-ABL1 transduced human cord blood cells

Several attempts have been made to model chronic myeloid leukemia (CML) in a xenograft setting but expansion of human myeloid cells in immunodeficient mice has proven difficult to achieve. Lack of cross-reacting cytokines in the microenvironment of the mice has been proposed as a potential reason. I...

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Vydáno v:PLoS One
Hlavní autoři: Askmyr, Maria, von Palffy, Sofia, Hansen, Nils, Landberg, Niklas, Högberg, Carl, Rissler, Marianne, Ågerstam, Helena, Fioretos, Thoas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638313/
https://ncbi.nlm.nih.gov/pubmed/29023488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186035
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