Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia

Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on cand...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ågerstam, Helena, Karlsson, Christine, Hansen, Nils, Sandén, Carl, Askmyr, Maria, von Palffy, Sofia, Högberg, Carl, Rissler, Marianne, Wunderlich, Mark, Juliusson, Gunnar, Richter, Johan, Sjöström, Kjell, Bhatia, Ravi, Mulloy, James C., Järås, Marcus, Fioretos, Thoas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553807/
https://ncbi.nlm.nih.gov/pubmed/26261316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422749112
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