Clonal competition within complex evolutionary hierarchies shapes AML over time

Clonal heterogeneity and evolution has major implications for disease progression and relapse in acute myeloid leukemia (AML). To model clonal dynamics in vivo, we serially transplanted 23 AML cases to immunodeficient mice and followed clonal composition for up to 15 months by whole-exome sequencing...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sandén, Carl, Lilljebjörn, Henrik, Orsmark Pietras, Christina, Henningsson, Rasmus, Saba, Karim H., Landberg, Niklas, Thorsson, Hanna, von Palffy, Sofia, Peña-Martinez, Pablo, Högberg, Carl, Rissler, Marianne, Gisselsson, David, Lazarevic, Vladimir, Juliusson, Gunnar, Ågerstam, Helena, Fioretos, Thoas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002407/
https://ncbi.nlm.nih.gov/pubmed/32024830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14106-0
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