Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient to cause chronic phase (CP) CM...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Askmyr, M, Ågerstam, H, Lilljebjörn, H, Hansen, N, Karlsson, C, von Palffy, S, Landberg, N, Högberg, C, Lassen, C, Rissler, M, Richter, J, Ehinger, M, Järås, M, Fioretos, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315895/
https://ncbi.nlm.nih.gov/pubmed/25501026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.89
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