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Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone

The frequency of stable DNA adducts in a target tissue can be used to assess biologically effective dose; however, the utility of the metric in a risk assessment context depends on the likelihood that the DNA damage will be manifested as mutation. Previously, we employed the Muta™Mouse system to exa...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mutagenesis
Main Authors: White, Paul A, Douglas, George R, Phillips, David H, Arlt, Volker M
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638019/
https://ncbi.nlm.nih.gov/pubmed/28096451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gew067
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