Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles

The intracellular fibroblast growth factors (iFGF/FHFs) bind directly to cardiac voltage gated Na(+) channels, and modulate their function. Mutations that affect iFGF/FHF-Na(+) channel interaction are associated with arrhythmia syndromes. Although suspected to modulate other ionic currents, such as...

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Dades bibliogràfiques
Publicat a:J Mol Cell Cardiol
Autors principals: Wang, Xiangchong, Tang, He, Wei, Eric Q., Wang, Zhihua, Yang, Jing, Yang, Rong, Wang, Sheng, Zhang, Yongjian, Pitt, Geoffrey S., Zhang, Hailin, Wang, Chuan
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637556/
https://ncbi.nlm.nih.gov/pubmed/28119060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.01.009
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