PHARMACOKINETICS OF ETHIONAMIDE DELIVERED IN SPRAY DRIED MICROPARTICLES TO THE LUNGS OF GUINEA PIGS

The use of ethionamide (ETH) in treating multi-drug resistant tuberculosis is limited by severe side effects. ETH disposition after pulmonary administration in spray dried particles might minimize systemic exposure and side effects. METHODS: Spray dried ETH particles were optimized for performance i...

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Publicado en:J Pharm Sci
Autores principales: Contreras, Lucila Garcia, Padilla-Carlin, Danielle J., Sung, Jean, VerBerkmoes, Jarod, Muttil, Pavan, Elbert, Katharina, Peloquin, Charles, Edwards, David, Hickey, Anthony
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637532/
https://ncbi.nlm.nih.gov/pubmed/27842973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.09.033
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