Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation

Inherited mutations in lipopolysaccharide-responsive beige-like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B-cell and antibody deficiency (common variable immunodeficiency), inflammatory bowel disease, enlarged spleen and lymph nodes, accumulation of activated T...

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Publicat a:Immunol Cell Biol
Autors principals: Burnett, Deborah L, Parish, Ian A, Masle-Farquhar, Etienne, Brink, Robert, Goodnow, Christopher C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636941/
https://ncbi.nlm.nih.gov/pubmed/28611475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2017.50
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