Exaggerated T Follicular Helper Cell Responses in LRBA Deficiency Due to Failure of CTLA4-Mediated Regulation

PURPOSE: LRBA (lipopolysaccharide-responsive beige like anchor protein) and CTLA4 (cytotoxic T lymphocyte antigen 4) deficiencies give rise to overlapping phenotypes of immune dysregulation and autoimmunity, with dramatically increased frequencies of circulating T Follicular helper (cT(FH)) cells. W...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Alroqi, Fayhan J., Charbonnier, Louis-Marie, Baris, Safa, Kiykim, Ayca, Chou, Janet, Platt, Craig D., Algassim, Abdulrahman, Keles, Sevgi, Al Saud, Bandar K., Alkuraya, Fowzan S., Jordan, Michael, Geha, Raif S., Chatila, Talal A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743769/
https://ncbi.nlm.nih.gov/pubmed/28601686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.05.022
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