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Molecular determinants of permeation in a fluoride-specific ion channel

Fluoride ion channels of the Fluc family combat toxicity arising from accumulation of environmental F(-). Although crystal structures are known, the densely packed pore region has precluded delineation of the ion pathway. Here we chart out the Fluc pore and characterize its chemical requirements for...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Last, Nicholas B, Sun, Senmiao, Pham, Minh C, Miller, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636608/
https://ncbi.nlm.nih.gov/pubmed/28952925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31259
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