Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, I(f), underlies exercise training–induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased inciden...

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Bibliografiset tiedot
Julkaisussa:Circ Res
Päätekijät: D’Souza, Alicia, Pearman, Charles M., Wang, Yanwen, Nakao, Shu, Logantha, Sunil Jit R.J., Cox, Charlotte, Bennett, Hayley, Zhang, Yu, Johnsen, Anne Berit, Linscheid, Nora, Poulsen, Pi Camilla, Elliott, Jonathan, Coulson, Jessica, McPhee, Jamie, Robertson, Abigail, da Costa Martins, Paula A., Kitmitto, Ashraf, Wisløff, Ulrik, Cartwright, Elizabeth J., Monfredi, Oliver, Lundby, Alicia, Dobrzynski, Halina, Oceandy, Delvac, Morris, Gwilym M., Boyett, Mark R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Lippincott Williams & Wilkins 2017
Aiheet:
Molecular Medicine
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636198/
https://ncbi.nlm.nih.gov/pubmed/28821541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311607
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