Immunoreceptor tyrosine-based inhibitory motif–dependent functions of an MHC class I-specific NK cell receptor

Natural killer (NK) cells express MHC class I (MHC-I)-specific receptors, such as Ly49A, that inhibit killing of cells expressing self–MHC-I. Self–MHC-I also “licenses” NK cells to become responsive to activating stimuli and regulates the surface level of NK-cell inhibitory receptors. However, the m...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bern, Michael D., Beckman, Diana L., Ebihara, Takashi, Taffner, Samantha M., Poursine-Laurent, Jennifer, White, J. Michael, Yokoyama, Wayne M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635927/
https://ncbi.nlm.nih.gov/pubmed/28923946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713064114
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