Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

Middle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of the respiratory tract both in humans and in its natural host, the dromedary camel. Virion attachment to host cells is mediated by 20-nm-long homotrimers of spike envelope protein S. The N-terminal subunit of each...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Wentao, Hulswit, Ruben J. G., Widjaja, Ivy, Raj, V. Stalin, McBride, Ryan, Peng, Wenjie, Widagdo, W., Tortorici, M. Alejandra, van Dieren, Brenda, Lang, Yifei, van Lent, Jan W. M., Paulson, James C., de Haan, Cornelis A. M., de Groot, Raoul J., van Kuppeveld, Frank J. M., Haagmans, Bart L., Bosch, Berend-Jan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635925/
https://ncbi.nlm.nih.gov/pubmed/28923942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712592114
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