Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

Middle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of the respiratory tract both in humans and in its natural host, the dromedary camel. Virion attachment to host cells is mediated by 20-nm-long homotrimers of spike envelope protein S. The N-terminal subunit of each...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Wentao, Hulswit, Ruben J. G., Widjaja, Ivy, Raj, V. Stalin, McBride, Ryan, Peng, Wenjie, Widagdo, W., Tortorici, M. Alejandra, van Dieren, Brenda, Lang, Yifei, van Lent, Jan W. M., Paulson, James C., de Haan, Cornelis A. M., de Groot, Raoul J., van Kuppeveld, Frank J. M., Haagmans, Bart L., Bosch, Berend-Jan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635925/
https://ncbi.nlm.nih.gov/pubmed/28923942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712592114
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