Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A

Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while related, originated from independent zoonotic introductions. OC43 is in fact a host-range variant of the species Betacoronavirus-1, and more closely related to bovine coronavirus (BCoV)—its presumptive ancestor—and po...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Hulswit, Ruben J. G., Lang, Yifei, Bakkers, Mark J. G., Li, Wentao, Li, Zeshi, Schouten, Arie, Ophorst, Bram, van Kuppeveld, Frank J. M., Boons, Geert-Jan, Bosch, Berend-Jan, Huizinga, Eric G., de Groot, Raoul J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377473/
https://ncbi.nlm.nih.gov/pubmed/30679277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809667116
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