Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Recent findings have revealed that the protein gasdermin D (GSDMD) plays key roles in cell pyroptosis. GSDMD binds lipids and forms pore structures to induce pyroptosis upon microbial infection and associated danger signals. However, detailed structural information for GSDMD remains unknown. Here, w...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kuang, Siyun, Zheng, Jun, Yang, Hui, Li, Suhua, Duan, Shuyan, Shen, Yanfang, Ji, Chaoneng, Gan, Jianhua, Xu, Xue-Wei, Li, Jixi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635896/
https://ncbi.nlm.nih.gov/pubmed/28928145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708194114
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