Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Recent findings have revealed that the protein gasdermin D (GSDMD) plays key roles in cell pyroptosis. GSDMD binds lipids and forms pore structures to induce pyroptosis upon microbial infection and associated danger signals. However, detailed structural information for GSDMD remains unknown. Here, w...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kuang, Siyun, Zheng, Jun, Yang, Hui, Li, Suhua, Duan, Shuyan, Shen, Yanfang, Ji, Chaoneng, Gan, Jianhua, Xu, Xue-Wei, Li, Jixi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635896/
https://ncbi.nlm.nih.gov/pubmed/28928145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708194114
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