Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Recent findings have revealed that the protein gasdermin D (GSDMD) plays key roles in cell pyroptosis. GSDMD binds lipids and forms pore structures to induce pyroptosis upon microbial infection and associated danger signals. However, detailed structural information for GSDMD remains unknown. Here, w...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kuang, Siyun, Zheng, Jun, Yang, Hui, Li, Suhua, Duan, Shuyan, Shen, Yanfang, Ji, Chaoneng, Gan, Jianhua, Xu, Xue-Wei, Li, Jixi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635896/
https://ncbi.nlm.nih.gov/pubmed/28928145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708194114
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