IgH isotype-specific B cell receptor expression influences B cell fate

Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble antibodies (sIg) or as membrane-bound (mIg) B cell receptors (BCRs) through alternative RNA splicing. IgH isotype dictates soluble antibody function, but how mIg isotype influences B cell behavior is not well d...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tong, Pei, Granato, Alessandra, Zuo, Teng, Chaudhary, Neha, Zuiani, Adam, Han, Seung Seok, Donthula, Rakesh, Shrestha, Akritee, Sen, Debattama, Magee, Jennifer M., Gallagher, Michael P., van der Poel, Cees E., Carroll, Michael C., Wesemann, Duane R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635877/
https://ncbi.nlm.nih.gov/pubmed/28923960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704962114
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