Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation

Two immunoglobulin (Ig) diversification mechanisms collaborate to provide protective humoral immunity. Combinatorial assembly of IgH and IgL V region exons from gene segments generates preimmune Ig repertoires, expressed as B cell receptors (BCRs). Secondary diversification occurs when Ig V regions...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Silver, Jared, Zuo, Teng, Chaudhary, Neha, Kumari, Rupa, Tong, Pei, Giguere, Sophie, Granato, Alessandra, Donthula, Rakesh, Devereaux, Colby, Wesemann, Duane R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748855/
https://ncbi.nlm.nih.gov/pubmed/29247044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171022
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