Agonist-Dependent and -Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes

We reported previously that the selective agonist U50,488H promoted phosphorylation of the mouse κ opioid receptor (KOPR) at residues S356, T357, T363, and S369. Here, we found that agonist (U50,488H)-dependent KOPR phosphorylation at all the residues was mediated by Gi/o(α) proteins and multiple pr...

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Vydáno v:Mol Pharmacol
Hlavní autoři: Chiu, Yi-Ting, Chen, Chongguang, Yu, Daohai, Schulz, Stefan, Liu-Chen, Lee-Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635518/
https://ncbi.nlm.nih.gov/pubmed/28893975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.108555
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