Phosphoproteomic approach for agonist-specific signaling in mouse brains: mTOR pathway is involved in κ opioid aversion

Kappa opioid receptor (KOR) agonists produce analgesic and anti-pruritic effects, but their clinical application was limited by dysphoria and hallucinations. Nalfurafine, a clinically used KOR agonist, does not cause dysphoria or hallucinations at therapeutic doses in humans. We found that in CD-1 m...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Liu, Jeffrey J., Chiu, Yi-Ting, DiMattio, Kelly M., Chen, Chongguang, Huang, Peng, Gentile, Taylor A., Muschamp, John W., Cowan, Alan, Mann, Matthias, Liu-Chen, Lee-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462019/
https://ncbi.nlm.nih.gov/pubmed/30082888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0155-0
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