Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance

Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense agai...

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Publicat a:Sci Rep
Autors principals: Itakura, Junya, Sato, Miwa, Ito, Toshihiro, Mino, Megumi, Fushimi, Soichiro, Takahashi, Sakuma, Yoshimura, Teizo, Matsukawa, Akihiro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634500/
https://ncbi.nlm.nih.gov/pubmed/28993690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13204-7
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