LSD1 protects against hippocampal and cortical neurodegeneration

To investigate the mechanisms that maintain differentiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice. Loss of LSD1 leads to paralysis, along with widespread hippocampus and cortex neurodegeneration, and learning and memory defects. We focus on the hippocampus n...

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Udgivet i:Nat Commun
Main Authors: Christopher, Michael A., Myrick, Dexter A., Barwick, Benjamin G., Engstrom, Amanda K., Porter-Stransky, Kirsten A., Boss, Jeremy M., Weinshenker, David, Levey, Allan I., Katz, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634471/
https://ncbi.nlm.nih.gov/pubmed/28993646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00922-9
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