Overcoming Resistance to Checkpoint Blockade Therapy by Targeting PI3K-γ in Myeloid Cells

Recent clinical trials using immunotherapy demonstrate its potential to control cancer by disinhibiting the immune system. Immune checkpoint blocking (ICB) antibodies such as anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) or anti-Programmed cell death protein 1/anti-Programmed death-...

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Publicado no:Nature
Main Authors: De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J, McGovern, Karen, Kutok, Jeffery L., Wolchok, Jedd D., Merghoub, Taha
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634331/
https://ncbi.nlm.nih.gov/pubmed/27828943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20554
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