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Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities
Antithrombin mainly inhibits factor Xa and thrombin. The reactive center loop (RCL) is crucial for its interactions with its protease targets and is fully inserted into the A-sheet after its cleavage, causing translocation of the covalently linked protease to the opposite end of the A-sheet. Antithr...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5633112/ https://ncbi.nlm.nih.gov/pubmed/28743742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787325 |
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