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Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities

Antithrombin mainly inhibits factor Xa and thrombin. The reactive center loop (RCL) is crucial for its interactions with its protease targets and is fully inserted into the A-sheet after its cleavage, causing translocation of the covalently linked protease to the opposite end of the A-sheet. Antithr...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Águila, Sonia, Izaguirre, Gonzalo, Martínez-Martínez, Irene, Vicente, Vicente, Olson, Steven T., Corral, Javier
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633112/
https://ncbi.nlm.nih.gov/pubmed/28743742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787325
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