Delayed Dosing of S-033188, a Novel Inhibitor of Influenza Virus Cap-dependent Endonuclease, Exhibited Significant Reduction of Viral Titer and Mortality in Mice Infected with Influenza A Virus

BACKGROUND: Both epidemic and pandemic influenza are major public health concerns, but current standard treatment limits its usage by 48 hours from onsets. Furthermore, no antiviral drug has been shown to definitively reduce serious complications, hospitalization, or mortality in a randomized clinic...

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Veröffentlicht in:Open Forum Infect Dis
Hauptverfasser: Fukao, Keita, Ando, Yoshinori, Noshi, Takeshi, Kawai, Makoto, Yoshida, Ryu, Shishido, Takao, Naito, Akira
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5631482/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx163.1210
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