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Simple Protein Modification Using Zwitterionic Polymer to Mitigate the Bioactivity Loss of Conjugated Insulin
Polymer–protein conjugation has been extensively explored toward a better protein drug with improved pharmacokinetics. However, a major problem with polymer–protein conjugation is that the polymers drastically reduce the bioactivity of the modified protein. There is no perfect solution to prevent th...
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| Published in: | Adv Healthc Mater |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5630064/ https://ncbi.nlm.nih.gov/pubmed/28337855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201601428 |
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