Glucose transporter inhibitor-conjugated insulin mitigates hypoglycemia

Insulin therapy in the setting of type 1 and advanced type 2 diabetes is complicated by increased risk of hypoglycemia. This potentially fatal complication could be mitigated by a glucose-responsive insulin analog. We report an insulin-facilitated glucose transporter (Glut) inhibitor conjugate, in w...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Wang, Jinqiang, Yu, Jicheng, Zhang, Yuqi, Kahkoska, Anna R., Wang, Zejun, Fang, Jun, Whitelegge, Julian P., Li, Song, Buse, John B., Gu, Zhen
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2019
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561193/
https://ncbi.nlm.nih.gov/pubmed/31097579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901967116
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