Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic processes to regain energy homeostasis. Cancer cells can occasionally suppress the growth restrictive AMPK pathway by mutation of an...

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Gepubliceerd in:Cell
Hoofdauteurs: Pineda, Carlos T., Ramanathan, Saumya, Tacer, Klementina Fon, Weon, Jenny L., Potts, Malia B., Ou, Yi-Hung, White, Michael A., Potts, Patrick Ryan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629913/
https://ncbi.nlm.nih.gov/pubmed/25679763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.034
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