Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic processes to regain energy homeostasis. Cancer cells can occasionally suppress the growth restrictive AMPK pathway by mutation of an...

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Udgivet i:Cell
Main Authors: Pineda, Carlos T., Ramanathan, Saumya, Tacer, Klementina Fon, Weon, Jenny L., Potts, Malia B., Ou, Yi-Hung, White, Michael A., Potts, Patrick Ryan
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629913/
https://ncbi.nlm.nih.gov/pubmed/25679763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.034
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