Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells

Ikaros is a transcription factor that regulates lymphocyte development from the level of the haematopoietic stem cell. Lack of Ikaros reduces the ability of progenitor cells to commit to the T‐cell lineage, resulting in reduced numbers of early thymic T‐cell progenitors and mature T cells. Mature CD...

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Bibliographic Details
Published in:Immunology
Main Authors: Agnihotri, Parul, Robertson, Nicholas M., Umetsu, Sarah E., Arakcheeva, Ksenia, Winandy, Susan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629446/
https://ncbi.nlm.nih.gov/pubmed/28670688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12786
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