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Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells
Ikaros is a transcription factor that regulates lymphocyte development from the level of the haematopoietic stem cell. Lack of Ikaros reduces the ability of progenitor cells to commit to the T‐cell lineage, resulting in reduced numbers of early thymic T‐cell progenitors and mature T cells. Mature CD...
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| Veröffentlicht in: | Immunology |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5629446/ https://ncbi.nlm.nih.gov/pubmed/28670688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12786 |
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