Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells

Ikaros is a transcription factor that regulates lymphocyte development from the level of the haematopoietic stem cell. Lack of Ikaros reduces the ability of progenitor cells to commit to the T‐cell lineage, resulting in reduced numbers of early thymic T‐cell progenitors and mature T cells. Mature CD...

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Vydáno v:Immunology
Hlavní autoři: Agnihotri, Parul, Robertson, Nicholas M., Umetsu, Sarah E., Arakcheeva, Ksenia, Winandy, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629446/
https://ncbi.nlm.nih.gov/pubmed/28670688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12786
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