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Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation
Inactivation of L-type calcium channel (Cav1.2) is an important determinant of the length of the cardiac action potential. Here, we report a key role of the voltage-sensing segment IS4 in Cav1.2 inactivation. Neutralization of IS4 charges gradually shifted the steady-state inactivation curve on the...
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| Publicado en: | Pflugers Arch |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer Berlin Heidelberg
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5629230/ https://ncbi.nlm.nih.gov/pubmed/28766141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-017-2038-3 |
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