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Timothy Mutation Disrupts the Link between Activation and Inactivation in Ca(V)1.2 Protein
The Timothy syndrome mutations G402S and G406R abolish inactivation of Ca(V)1.2 and cause multiorgan dysfunction and lethal arrhythmias. To gain insights into the consequences of the G402S mutation on structure and function of the channel, we systematically mutated the corresponding Gly-432 of the r...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3173108/ https://ncbi.nlm.nih.gov/pubmed/21685391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255273 |
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