Timothy Mutation Disrupts the Link between Activation and Inactivation in Ca(V)1.2 Protein

The Timothy syndrome mutations G402S and G406R abolish inactivation of Ca(V)1.2 and cause multiorgan dysfunction and lethal arrhythmias. To gain insights into the consequences of the G402S mutation on structure and function of the channel, we systematically mutated the corresponding Gly-432 of the r...

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Bibliografiske detaljer
Main Authors: Depil, Katrin, Beyl, Stanislav, Stary-Weinzinger, Anna, Hohaus, Annette, Timin, Eugen, Hering, Steffen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173108/
https://ncbi.nlm.nih.gov/pubmed/21685391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255273
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