Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation

Inactivation of L-type calcium channel (Cav1.2) is an important determinant of the length of the cardiac action potential. Here, we report a key role of the voltage-sensing segment IS4 in Cav1.2 inactivation. Neutralization of IS4 charges gradually shifted the steady-state inactivation curve on the...

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Vydáno v:Pflugers Arch
Hlavní autoři: Andranovits, Stanislav, Beyl, Stanislav, Hohaus, Annette, Zangerl-Plessl, Eva Maria, Timin, Eugen, Hering, Steffen
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2017
Témata:
Ion channels, Receptors and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629230/
https://ncbi.nlm.nih.gov/pubmed/28766141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-017-2038-3
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