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Tuning SpyTag–SpyCatcher mutant pairs toward orthogonal reactivity encryption

Genetically encoded covalent peptide tagging technology, such as the SpyTag–SpyCatcher reaction, has emerged as a unique way to do chemistry with proteins. Herein, we report the reactivity engineering of SpyTag–SpyCatcher mutant pairs and show that distinct reactivity can be encrypted for the same r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chem Sci
Hauptverfasser: Liu, Yajie, Liu, Dong, Yang, Wei, Wu, Xia-Ling, Lai, Luhua, Zhang, Wen-Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627348/
https://ncbi.nlm.nih.gov/pubmed/28989685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02686b
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