Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Combining immunostimulants in adjuvants can improve the quality of the immune response to vaccines. Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4’-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System A...

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Detaylı Bibliyografya
Yayımlandı:NPJ Vaccines
Asıl Yazarlar: Coccia, Margherita, Collignon, Catherine, Hervé, Caroline, Chalon, Aurélie, Welsby, Iain, Detienne, Sophie, van Helden, Mary J., Dutta, Sheetij, Genito, Christopher J., Waters, Norman C., Van Deun, Katrijn, Smilde, Age K., van den Berg, Robert A., Franco, David, Bourguignon, Patricia, Morel, Sandra, Garçon, Nathalie, Lambrecht, Bart N., Goriely, Stanislas, van der Most, Robbert, Didierlaurent, Arnaud M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627273/
https://ncbi.nlm.nih.gov/pubmed/29263880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-017-0027-3
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