Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

The adjuvant properties of the saponin QS-21 have been known for decades. It is a component of the Adjuvant System AS01 that is used in several vaccine candidates. QS-21 strongly potentiates both cellular and humoral immune responses to purified antigens, yet how it activates immune cells is largely...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Welsby, Iain, Detienne, Sophie, N’Kuli, Francisca, Thomas, Séverine, Wouters, Sandrine, Bechtold, Viviane, De Wit, Dominique, Gineste, Romain, Reinheckel, Thomas, Elouahabi, Abdelatif, Courtoy, Pierre J., Didierlaurent, Arnaud M., Goriely, Stanislas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215313/
https://ncbi.nlm.nih.gov/pubmed/28105029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00663
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