Central Role of CD169(+) Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

Saponins represent a promising class of vaccine adjuvant. Together with the TLR4-ligand MPL, QS-21 is part of the Adjuvant System AS01, a key component of the malaria and zoster candidate vaccines that display demonstrated clinical efficacy. However, the mechanism of action of QS-21 in this liposoma...

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Pubblicato in:Sci Rep
Autori principali: Detienne, Sophie, Welsby, Iain, Collignon, Catherine, Wouters, Sandrine, Coccia, Margherita, Delhaye, Sophie, Van Maele, Laurye, Thomas, Séverine, Swertvaegher, Maëlle, Detavernier, Aurélie, Elouahabi, Abdelatif, Goriely, Stanislas, Didierlaurent, Arnaud M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5172233/
https://ncbi.nlm.nih.gov/pubmed/27996000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39475
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