Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties

The oil-in-water emulsion Adjuvant System 03 (AS03) is one of the few adjuvants used in licensed vaccines. Previous work indicates that AS03 induces a local and transient inflammatory response that contributes to its adjuvant effect. However, the molecular mechanisms involved in its immunostimulator...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Givord, Charlotte, Welsby, Iain, Detienne, Sophie, Thomas, Séverine, Assabban, Assiya, Lima Silva, Viviana, Molle, Céline, Gineste, Romain, Vermeersch, Marjorie, Perez-Morga, David, Leo, Oberdan, Collignon, Catherine, Didierlaurent, Arnaud M., Goriely, Stanislas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6023910/
https://ncbi.nlm.nih.gov/pubmed/29977610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0058-4
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