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A machine-learning heuristic to improve gene score prediction of polygenic traits

Machine-learning techniques have helped solve a broad range of prediction problems, yet are not widely used to build polygenic risk scores for the prediction of complex traits. We propose a novel heuristic based on machine-learning techniques (GraBLD) to boost the predictive performance of polygenic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Paré, Guillaume, Mao, Shihong, Deng, Wei Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627249/
https://ncbi.nlm.nih.gov/pubmed/28979001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13056-1
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