NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

NF-κB signaling is essential for osteoclast differentiation and skeletal homeostasis. We have reported recently that NUMB-like (NUMBL) protein modulates osteoclastogenesis by down regulating NF-κB activation. Herein, we decipher the mechanism underlying this phenomenon. We found that whereas NUMBL m...

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Udgivet i:Sci Rep
Main Authors: Swarnkar, Gaurav, Chen, Tim Hung-Po, Arra, Manoj, Nasir, Amjad M., Mbalaviele, Gabriel, Abu-Amer, Yousef
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626749/
https://ncbi.nlm.nih.gov/pubmed/28974699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12707-7
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