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Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
Inflammatory osteolysis is governed by exacerbated osteoclastogenesis. Ample evidence points to central role of NF-κB in such pathologic responses, yet the precise mechanisms underpinning specificity of these responses remain unclear. We propose that motifs of the scaffold protein IKKγ/NEMO partly f...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7145425/ https://ncbi.nlm.nih.gov/pubmed/32202502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56095 |
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