Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

Inflammatory osteolysis is governed by exacerbated osteoclastogenesis. Ample evidence points to central role of NF-κB in such pathologic responses, yet the precise mechanisms underpinning specificity of these responses remain unclear. We propose that motifs of the scaffold protein IKKγ/NEMO partly f...

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Vydáno v:eLife
Hlavní autoři: Adapala, Naga Suresh, Swarnkar, Gaurav, Arra, Manoj, Shen, Jie, Mbalaviele, Gabriel, Ke, Ke, Abu-Amer, Yousef
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Human Biology and Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145425/
https://ncbi.nlm.nih.gov/pubmed/32202502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56095
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