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Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking
Shiga toxins 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol. Early endosome-to-Golgi transport allows the toxins to evade degradation in lysosomes. Targeting this trafficking step has therapeutic promise, but the mechanism of trafficking for the more potent toxin STx2 is...
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| Pubblicato in: | J Cell Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5626549/ https://ncbi.nlm.nih.gov/pubmed/28883040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201704015 |
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